Alfred steele death cause11/21/2023 While high-quality data in richer countries often exists, data on deaths from diarrheal diseases in many poorer countries is often limited. There are large differences in the quality and availability of data on diarrheal disease deaths across the world. The findings were then extrapolated globally, to estimate the number of deaths worldwide caused by each pathogen, using additional data collected from previous studies, such as the Global Burden of Disease study.They tested stool samples for various pathogens using molecular techniques and compared these to controls. The authors used high-quality data from the Global Pediatric Diarrhea Surveillance (GPDS) network, which included large general hospitals in 28 countries of different income levels.Estimates for the fraction of diarrheal deaths caused by each pathogen come from a study by Adam Cohen et al.This is therefore also true for all global figures. The IHME Global Burden of Disease attempts to fill these gaps, but these estimates come with a level of uncertainty. There are large differences in the quality and availability of data across the world.This data was then used to estimate a single underlying cause of death for all deaths in the Global Burden of Disease study.Estimates of diarrheal deaths are based on vital registration and verbal autopsy data and a range of hospital and community samples where pathogens were identified using cell culture, immunoassay, and RT-PCR techniques.This is currently one of the few sources that produces global-level estimates across most countries on the prevalence and disease burden of diarrheal diseases. These estimates come from the Global Burden of Disease study published annually by the Institute for Health Metrics (IHME).
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